Replication timing control can be maintained in extrachromosomally amplified genes
نویسندگان
چکیده
منابع مشابه
Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells.
Gene amplification is one mechanism mediating the resistance of tumor cells to antineoplastic agents and the overexpression of a variety of oncogenes in diverse tumor types. There is mounting evidence that acentric extrachromosomal elements such as double minute chromosomes are common intermediates in the amplification process. These acentric structures partition unequally at mitosis and can be...
متن کاملHydroxyurea Accelerates Loss of Extrachromosomally Amplified Genes from Tumor Cells1
Gene amplification is one mechanism mediating the resistance of tumor cells to antineoplastic agents and the overexpression of a variety of oncogenes in diverse tumor types. There is mounting evidence that acentric extrachromosomal elements such as double minute chromosomes are common intermediates in the amplification process. These acentric structures partition unequally at mitosis and can be...
متن کاملReplication factory activation can be decoupled from the replication timing program by modulating Cdk levels
In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in mammalian nuclei. Although replicative stress caused checkpoint-induced slowing of the timing program, inhibition of checkpoint kinases in an ...
متن کاملCan body temperature be maintained during aeromedical transport?
BACKGROUND Aeromedical transport in northern areas may be associated with hypothermia. The objective of this study was to determine whether significant hypothermia (core temperature <35 masculineC) occurs in severely injured or ill intubated patients during transport by rotary wing aircraft. METHODS In this prospective cohort study, all intubated patients over 16 years of age who were transpo...
متن کاملCan Stable Social Groups Be Maintained by Homophilous Imitation Alone?
A central problem in the biological and social sciences concerns the conditions required for emergence and maintenance of cooperation among unrelated individuals. Most models and experiments have been pursued in a game-theoretic context and involve reward or punishment. Here we show that such payoffs are unnecessary, and that stable social groups can sometimes be maintained provided simply that...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1991
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.11.9.4779-4785.1991